The biostatistical minimum

Biostatistical Methods and Research Designs

In Biostatistical Training for Residents

Each year, a new crop of physicians enters residency training programs in medical teaching institutions worldwide. Second and subsequent year residents continue with the programs in which they have participated in a prior year. The educational curriculum may include a biostatistical component, where the instructor is presented with an opportunity to focus on biostatistical issues bearing on var...

Biostatistical Methodology in Clinical Trials

Status Last revised May 1993 Previous titles/other references Biostatistical methodology in clinical trials in applications for Marketing Authorisations for Medicinal Products/ III/3630/92, Additional Notes This note for guidance concerns the application of Part 4, sections C and F of the Annex to Directive 75/318/EEC as amended with a view to the granting of a marketing authorisation for a med...

Evaluation metrics for biostatistical and epidemiological collaborations.

Increasing demands for evidence-based medicine and for the translation of biomedical research into individual and public health benefit have been accompanied by the proliferation of special units that offer expertise in biostatistics, epidemiology, and research design (BERD) within academic health centers. Objective metrics that can be used to evaluate, track, and improve the performance of the...

Biostatistical aspects of genome-wide association studies.

To search the entire human genome for association is a novel and promising approach to unravelling the genetic basis of complex genetic diseases. In these genome-wide association studies (GWAs), several hundreds of thousands of single nucleotide polymorphisms (SNPs) are analyzed at the same time, posing substantial biostatistical and computational challenges. In this paper, we discuss a number ...